Cobra Biologics

Cobra provides a comprehensive biologics and pharmaceuticals service offering, with multi-functional and experienced project teams nurturing customers’ products through to clinical and commercial manufacture.

Expertise

Cobra is a rapidly expanding international contract manufacturing organization (CMO) of biologics and pharmaceuticals for clinical and commercial supply. Cobra has three GMP approved facilities, each with expertise tailored to serving our customers across the world. We offer a broad range of integrated and stand-alone contract services; stretching from cell line and process development through to fill and finish for the supply of investigational medicinal products and commercial production.

Experience

For over 16 years we have taken pride in being a trusted manufacturing provider, delivering what we promise and helping our customers to develop medicines for the benefit of patients. Cobra provides manufacturing technologies, platforms and solutions to the pharmaceutical industry covering antibodies, recombinant proteins, viruses, phage, DNA as gene therapies, whole cell vaccines and therapeutics as well as biologics and small molecule API lyophilisation and fill finish.

Cobra’s MaxXpress service optimises cell-line development using a unique technology that infuses Ubiquitous Chromatin-Opening Element (UCOE) technology with cell-line development expertise to yield increased recombinant protein and antibody production. 100-300mg of material can be produced in under 10 weeks.

Cobra uses Ambr™ micro bioreactor technology from TAP Biosystems for evaluation of process parameters. The better monitoring, process control capability and speed (weeks not months), compared to shake flask culture or bioreactors, is a significant advantage and allows data on the cells’ behaviour and product characteristics to be collected before larger bioreactor studies. This ensures superior product similarity to that achieved in a large scale bioreactor.

Excellence

At Cobra, we recognize the value of transparent and effective communications with our customers. We ensure that we provide regular progress updates as well as respond to our customers’ needs. Large enough to deliver and small enough to care, Cobra dedicates the attention and resources needed with multidisciplinary teams that remain with each program throughout its life. This seamless integration reduces both transfer risk and time delays, thereby increasing customer satisfaction. Delivering the highest quality products on schedule through trusted relationships ensures that our customers come back for further clinical development and production or with new projects.

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Locations


United Kingdom
Keele cGMP Manufacturing
Stephenson Building
Keele Science Park
Keele,   ST5 5SP
United Kingdom, Europe

GMP Experience
The Keele facility is based in the UK and supports multiple GMP requirements for bacterial proteins, viruses, DNA, gene therapy, phage and cell products.
Sweden
Södertälje cGMP Manufacturing
Gärtunavägen 10
Södertälje,
Sweden, Europe

GMP Experience
The Södertalje facility is amongst the most modern and flexible in the industry. In an open and stimulating environment, all scientific disciplines are integrated for fast and effective development.
Sweden
Matfors cGMP Manufacturing
Storjordenvägen 2

Matfors,
Sweden, Europe

GMP Experience
The Matfors facility has a new state-of-the-art fill and finish service to provide manufacturing for both biologics and pharmaceutical drugs up to commercial supply.

Contacts


Jason Rahal
Sr VP Business Development
Philip Ridley-Smith
Sales & Marketing Director
Magnus Gustafsson
Sales Director
Patrick Lansky
Director of Business Development

Production Lines

Keele cGMP Manufacturing   50L disposable bioreactor
Location: Keele, United Kingdom
Main Details
Specialization:  Drug Substance (API)Drug Substance (API)
Platform:  MicrobialMicrobial
BioReactor Process:  BatchBatch
BioReactor Scale:  1L-100L50L Bioreactor
GMP Level:  Phase I/IIPhase I/II
Biosafety Level:  Biosafety Level 2Biosafety Level 2
Single Use:  AllAll
Additional Services
Analytical Services are AvailableAnalytical Services
Cell Banking is AvailableCell Banking
Cell Line Development is AvailableCell Line Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Process Development is AvailableProcess Development
Viral Manufacturing is AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

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Keele cGMP Manufacturing   50L Fermentation
Location: Keele, United Kingdom
Main Details
Specialization:  Drug Substance (API)Drug Substance (API)
Platform:  MicrobialMicrobial
BioReactor Process:  BatchBatch
BioReactor Process:  Fed-BatchFed-Batch
BioReactor Scale:  1L-100L50L Bioreactor
GMP Level:  Phase I/IIPhase I/II
Biosafety Level:  Biosafety Level 2Biosafety Level 2
Single Use:  NoneNone
Additional Services
Analytical Services are AvailableAnalytical Services
Cell Banking is AvailableCell Banking
Cell Line Development is AvailableCell Line Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Process Development is AvailableProcess Development
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Contact CMO

Last Update: 17MAY17

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Keele cGMP Manufacturing   50L wave system
Location: Keele, United Kingdom
Main Details
Specialization:  Drug Substance (API)Drug Substance (API)
Platform:  Cell CultureCell Culture
BioReactor Scale:  1L-100L50L Bioreactor
GMP Level:  Phase I/IIPhase I/II
Biosafety Level:  Biosafety Level 2Biosafety Level 2
Single Use:  AllAll
Additional Services
Analytical Services are AvailableAnalytical Services
Cell Banking is AvailableCell Banking
Cell Line Development is AvailableCell Line Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Process Development is AvailableProcess Development
Viral Manufacturing is AvailableViral Manufacturing
Availability: Contact CMO

Last Update: 17MAY17

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Matfors cGMP Manufacturing   Fill Finish Liquid
Location: Matfors, Sweden
Main Details
Specialization:  Drug Product (Fill/Finish)Drug Product (Fill/Finish)
Dosage Form:  LiquidLiquid
Batch Size:  1-5,0001-5,000
Supported Vial Size:  2 ml2 ml
Supported Vial Size:  3 ml3 ml
Supported Vial Size:  5 ml5 ml
Supported Vial Size:  10 ml10 ml
Supported Vial Size:  20 ml20 ml
Supported Vial Size:  20+ ml20+ ml
GMP Level:  CommercialCommercial
Biosafety Level:  Biosafety Level 2Biosafety Level 2
Additional Services
Analytical Services are AvailableAnalytical Services
Formulation Development is AvailableFormulation Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Stability Studies are AvailableStability Studies
Prefilled Syringes are AvailablePrefilled Syringes
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

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Södertälje cGMP Manufacturing   Antibody Production 250L
Location: Södertälje, Sweden
Main Details
Specialization:  Drug Substance (API)Drug Substance (API)
Platform:  Cell CultureCell Culture
BioReactor Process:  BatchBatch
BioReactor Process:  Fed-BatchFed-Batch
BioReactor Process:  PerfusionPerfusion
BioReactor Scale:  100L-2000L250L Bioreactor
GMP Level:  Phase I/IIPhase I/II
Biosafety Level:  Biosafety Level 1Biosafety Level 1
Single Use:  AllAll
Additional Services
Analytical Services are AvailableAnalytical Services
Cell Banking is AvailableCell Banking
Cell Line Development is AvailableCell Line Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Process Development is AvailableProcess Development
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

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Matfors cGMP Manufacturing   Fill Finish + Lyophilisation
Location: Matfors, Sweden
Main Details
Specialization:  Drug Product (Fill/Finish)Drug Product (Fill/Finish)
Dosage Form:  LiquidLiquid
Batch Size:  1-5,0001-5,000
Supported Vial Size:  2 ml2 ml
Supported Vial Size:  3 ml3 ml
Supported Vial Size:  5 ml5 ml
Supported Vial Size:  10 ml10 ml
Supported Vial Size:  20+ ml20+ ml
GMP Level:  CommercialCommercial
Biosafety Level:  Biosafety Level 1Biosafety Level 1
Additional Services
Analytical Services are AvailableAnalytical Services
Formulation Development is AvailableFormulation Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Stability Studies are AvailableStability Studies
Prefilled Syringes are AvailablePrefilled Syringes
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

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Södertälje cGMP Manufacturing   Antibody Production 1000L SUB
Location: Södertälje, Sweden
Main Details
Specialization:  Drug Substance (API)Drug Substance (API)
Platform:  Cell CultureCell Culture
BioReactor Process:  BatchBatch
BioReactor Process:  Fed-BatchFed-Batch
BioReactor Process:  PerfusionPerfusion
BioReactor Scale:  100L-2000L1000L Bioreactor
GMP Level:  Phase I/IIPhase I/II
Biosafety Level:  Biosafety Level 1Biosafety Level 1
Single Use:  AllAll
Additional Services
Analytical Services are AvailableAnalytical Services
Cell Banking is AvailableCell Banking
Cell Line Development is AvailableCell Line Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Process Development is AvailableProcess Development
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

Send Inquiry about this Production Line
Södertälje cGMP Manufacturing   Antibody Production 1000L SUB
Location: Södertälje, Sweden
Main Details
Specialization:  Drug Substance (API)Drug Substance (API)
Platform:  Cell CultureCell Culture
BioReactor Process:  BatchBatch
BioReactor Process:  Fed-BatchFed-Batch
BioReactor Process:  PerfusionPerfusion
BioReactor Scale:  100L-2000L1000L Bioreactor
GMP Level:  Phase IIIPhase III
Biosafety Level:  Biosafety Level 1Biosafety Level 1
Single Use:  AllAll
Additional Services
Analytical Services are AvailableAnalytical Services
Cell Banking is AvailableCell Banking
Cell Line Development is AvailableCell Line Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Process Development is AvailableProcess Development
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

Send Inquiry about this Production Line
Matfors cGMP Manufacturing   Fill Finish Liquid
Location: Matfors, Sweden
Main Details
Specialization:  Drug Product (Fill/Finish)Drug Product (Fill/Finish)
Dosage Form:  LiquidLiquid
Batch Size:  5,000-20,0005,000-20,000
Supported Vial Size:  2 ml2 ml
Supported Vial Size:  3 ml3 ml
Supported Vial Size:  5 ml5 ml
Supported Vial Size:  10 ml10 ml
Supported Vial Size:  20 ml20 ml
Supported Vial Size:  20+ ml20+ ml
GMP Level:  CommercialCommercial
Biosafety Level:  Biosafety Level 1Biosafety Level 1
Additional Services
Analytical Services are AvailableAnalytical Services
Formulation Development is AvailableFormulation Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Stability Studies are AvailableStability Studies
Prefilled Syringes are AvailablePrefilled Syringes
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

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Keele cGMP Manufacturing   Fill Finish Liquid (1,000-40,000)
Location: Keele, United Kingdom
Main Details
Specialization:  Drug Product (Fill/Finish)Drug Product (Fill/Finish)
Dosage Form:  LiquidLiquid
Batch Size:  20,000-50,00020,000-50,000
Supported Vial Size:  2 ml2 ml
Supported Vial Size:  3 ml3 ml
Supported Vial Size:  5 ml5 ml
Supported Vial Size:  10 ml10 ml
Supported Vial Size:  20 ml20 ml
Supported Vial Size:  20+ ml20+ ml
GMP Level:  CommercialCommercial
Biosafety Level:  Biosafety Level 1Biosafety Level 1
Additional Services
Analytical Services are AvailableAnalytical Services
Formulation Development is Not AvailableFormulation Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Stability Studies are AvailableStability Studies
Prefilled Syringes are AvailablePrefilled Syringes
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

Send Inquiry about this Production Line
Södertälje cGMP Manufacturing   Antibody Production 1000L SUB
Location: Södertälje, Sweden
Main Details
Specialization:  Drug Substance (API)Drug Substance (API)
Platform:  Cell CultureCell Culture
BioReactor Process:  BatchBatch
BioReactor Process:  Fed-BatchFed-Batch
BioReactor Process:  PerfusionPerfusion
BioReactor Scale:  100L-2000L1000L Bioreactor
GMP Level:  Phase IIIPhase III
Biosafety Level:  Biosafety Level 1Biosafety Level 1
Single Use:  AllAll
Additional Services
Analytical Services are AvailableAnalytical Services
Cell Banking is AvailableCell Banking
Cell Line Development is AvailableCell Line Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Process Development is AvailableProcess Development
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

Send Inquiry about this Production Line
Matfors cGMP Manufacturing   Fill Finish + Lyophilization (1,000 -15,000)
Location: Matfors, Sweden
Main Details
Specialization:  Drug Product (Fill/Finish)Drug Product (Fill/Finish)
Dosage Form:  LiquidLiquid
Batch Size:  5,000-20,0005,000-20,000
Supported Vial Size:  2 ml2 ml
Supported Vial Size:  3 ml3 ml
Supported Vial Size:  5 ml5 ml
Supported Vial Size:  10 ml10 ml
Supported Vial Size:  20+ ml20+ ml
GMP Level:  CommercialCommercial
Biosafety Level:  Biosafety Level 1Biosafety Level 1
Additional Services
Analytical Services are AvailableAnalytical Services
Formulation Development is AvailableFormulation Development
Preclinical Manufacturing is AvailablePreclinical Manufacturing
Stability Studies are AvailableStability Studies
Prefilled Syringes are AvailablePrefilled Syringes
Viral Manufacturing is Not AvailableViral Manufacturing
Availability: Available

Last Update: 17MAY17

Send Inquiry about this Production Line

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